Cell Chemistry

Location
Im Neuenheimer Feld 360, 1.OG
69120 Heidelberg

Director
Prof. Dr. S. Strahl
eMail
office: INF360, 1st floor, R 113
office hour: Friday 13.00-14.00 Uhr

The Strahl Lab - Glycobiology: Sweet Science
Glycosylation is one of the most abundant and complex protein modifications known. In many biological systems more than half of all proteins are glycosylated and glycan chains are highly crucial for a wide range of biological processes.
Our laboratory is interested in various aspects of glycobiology in eukaryotic organisms with a main focus on O-mannosylation, an evolutionarily conserved, essential protein modification with immense impact on a variety of cellular processes. Having identified the first protein O-mannosyltransferase PMT1 in the model organism yeast, our work has substantially contributed to the understanding of protein O-mannosylation in eukaryotes.The laboratory continues to work on the molecular organization of the O-mannosylation machinery in the ER and the role of O-mannosyl glycans for growth and developement.

Research Projects
Structure and dynamics of the protein O-mannosylation>>>SFB638
Functions of O-mannosyl glycans >>>
Protein O-mannosylation in mammals >>>


Latest Publication
Hutzler F, Gerstl R, Lommel M, Strahl S. (2008)
Protein N-glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p. Mol Microbiol.68:1438 abstract

Activities outside Lab

Lab Members

• Prof. Dr. Sabine Strahl (Director)
• Dr. habil. Michael Büttner (Research group leader)
• Dr. Thomas Jank (Postdoc)
• Dr. Mark Lommel (PostDoc)
• Dipl. Biol. Martin Loibl (Graduate Student)
• Dipl. Biol. Gernot Poschet (Ph.D. Student)
• Dipl. Biol. Andrea Schott (Graduate student)
• Dipl. Biol. Lisa Weber (Ph.D. Student)
• Dipl.-Biol. Claudia Müller (Technical assistant)